A peptide-based vaccine for Mycobacterium avium subspecies paratuberculosis
نویسندگان
چکیده
منابع مشابه
The Mycobacterium avium Subspecies Paratuberculosis Dilemma
The purpose of this paper is to present and update the longitudinal perspective of the Mycobacterium avium subspecies paratuberculosis dilemma as initially stated in Infectious Diseases Incorporated’s 2012 White Paper. In both wild and domestic herbivores, Mycobacterium avium subspecies paratuberculosis (MAP) produces chronic granulomatous enteritis (Johne’s disease) that, if unchecked, is usua...
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Mycobacterium avium subspecies paratuberculosis (MAP), is the etiological agent of Johne's disease (or paratuberculosis) in animals and has also been linked with Crohn's disease of human beings. Extreme fastidious nature of the organism (MAP) has hampered studies on diversity within the organism. Studies based on phenotypic properties like growth rate, pigmentation, lipid profile etc., are unab...
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The aim of this study is to identify, clone and express a Mycobacterium avium subsp. paratuberculosis specific immunogenic antigen candidate, in order to develop better reagents for diagnosis and vaccines for the protection of the host. Therefore, MAP2191 gene (a member of MAPmce5 operon) from MAP, was isolated and characterized by Bioinformatics tools and <e...
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BACKGROUND Mycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including primates. Humans are exposed through milk and from sources of environmental contamination. Hitherto, the only vaccines available against Mycobacterium avium subspecies paratuberculosis have been limited to veterinary use and comprised attenuated or k...
متن کاملMycobacterium avium subspecies paratuberculosis and its relationship with Crohn's disease.
The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn's disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CD. Recently, genome-wide association studies have identified novel suscep...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2019
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2019.04.040